Woody, Buzz Lightyear, and the other toys are accidentally donated to a daycare center by Andy's mother, and the toys must decide where their loyalties lie. In the film's ensemble voice cast, Tom Hanks, Tim Allen, Joan Cusack, Don Rickles, Wallace Shawn, John Ratzenberger, Estelle Harris, Jeff Pidgeon, Jodi Benson, John Morris, Laurie Metcalf and R. Lee Ermey (in his final voice role as Sarge before his death on April 15, 2018), reprise their roles from previous films.

Jim Varney, who voiced Slinky Dog in the first two films, died on February 10, 2000, 10 years before the release of the third film, so the role of Slinky was passed down to Blake Clark. The returning cast is joined by Ned Beatty, Michael Keaton, Whoopi Goldberg, Timothy Dalton, Kristen Schaal, Bonnie Hunt, and Jeff Garlin who voice the new characters introduced in this film. The film was released in the United States on June 18, 2010. Toy Story 3 was the first film to be released theatrically with Dolby Surround 7.1 sound. Like its predecessors, Toy Story 3 received critical acclaim upon release, with critics praising the vocal performances, screenplay, emotional depth, animation, and Randy Newman's musical score. It became the second Pixar film (after Up) and third animated film overall (after Beauty and the Beast and Up), as well as the third film produced by Walt Disney Pictures to receive an Academy Award nomination for Best Picture. The film received four more Academy Award nominations for Best Adapted Screenplay, Best Sound Editing, Best Animated Feature and Best Original Song, winning the latter two.

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